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Risk Factors of Endometrial Cancer

Endometrial cancer develops when malignant (cancer) cells develop in the uterine lining tissue, known as the endometrium.

Uterine cancer is another name for endometrial cancer. Without therapy, it may progress to other organs like the rectum, fallopian tubes, bladder, and ovaries.

However, since irregular vaginal bleeding occurs often, endometrial cancer is typically found at an early stage and progresses slowly.

When endometrial cancer is caught early, it may often be treated surgically by eliminating the uterus. Endometrial cancer may result from elevated levels of the oestrogen hormone.

Also Read- Types Of Endometrial Cancer

Risk Factors of Endometrial Cancer 


Some of the following may have a role in the development of endometrial cancer:

  • Hormone balance

Oestrogen and progesterone are the two primary female hormones produced by the ovaries. The endometrium responds differently to fluctuations in the equilibrium of these hormones.

The chance of developing endometrial cancer is raised if your body produces more oestrogen than usual but a normal amount of progesterone. PCOS, obesity, and diabetes are among the conditions that may cause irregular ovulation. 

Endometrial cancer risk is raised when oestrogen-only hormone replacement is used after menopause. 

  • First Menstruation at a Young Age or a Delayed Menopause

The chance of developing endometrial cancer increases if menstruation begins before the age of 12 or if menopause is delayed until beyond 50.

The endometrium of a menstrual woman is constantly being bombarded by oestrogen. The endometrium is more and more exposed to oestrogen when a woman has more and more cycles.

  • Never Been Pregnant

Women with infertility concerns or who have never gotten pregnant are at the greatest risk. Because your body produces more progesterone than oestrogen during pregnancy, having children helps prevent endometrial cancer by giving your body a little respite from the hormone.

  • Age 

As you become older, you increase your risk of developing endometrial cancer. Menopause is associated with an increase in endometrial cancer.

  • Obesity

After menopause, the ovaries stop generating oestrogen, but the hormone is still present in the body in adipose tissue or fat. Nothing unusual here; all women experience this. Higher oestrogen levels contribute to the greater risk of endometrial cancer in obese women, who tend to have more fatty tissue. 

Women who are overweight and have endometrial cancer have a much higher mortality rate. Do not forget that women of normal weight are at risk for developing endometrial cancer.

  • Hormone therapy for breast cancer 

The use of tamoxifen, a hormone treatment medicine used to treat breast cancer, has been linked to an increase in the occurrence of endometrial cancer.

Talk to your endometrial cancer surgeon in Mumbai about this potential side effect if you take tamoxifen. In most cases, the advantages of tamoxifen exceed the low risk of developing endometrial cancer.

  • Previous cancer diagnosis

Endometrial cancer is more common in women with a record of either endometrial or colorectal cancer in their families. With a median age of 49, women with the MLH1 or MSH2 mutations associated with Lynch syndrome have an increased chance of developing endometrial cancer over their lifetime.

Women with MSH6 mutations are at the same risk for developing endometrial cancer as other women, although they are often diagnosed later.

Related, Read- Symptoms of Endometrial Cancer

Endometrial Cancer



The oestrogen levels in your body might rise if you eat foods that include a lot of saturated fat or sugar. Anyone with these indicators should see a doctor often since cancer can often be cured if caught early.

You should see a doctor if you have any signs of endometrial cancer or any gynaecological disorder. Abnormal vaginal bleeding is the most common indicator of endometrial cancer, although it may also indicate other illnesses. Many diseases, including endometrial cancer, benefit greatly from early detection and treatment.


    About Author

    Dr. Nilesh is a renowned Cancer surgeon/consultant practicing at SSO Hospital, Infinity Media Surge Hospital, and Navkaar Cancer Clinic Mumbai and he is also a visiting consultant at various hospitals in Mumbai, Thane, Dombivali, Kalyan, Navi Mumbai, etc. With over 10+ years of experience, he is highly trained and specialized in performing GI & Gynae cancer surgery procedures from the simplest to the most complicated surgeries.